What’s the cost of a flight from Santo Domingo to Guayaquil?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Santo Domingo and Guayaquil.

Choose a date to explore the best fares now.

If possible, avoid holiday periods: ticket prices tend to rise quickly and availability drops, especially on busy routes. Morning and evening flights are often in high demand too — book early to get a good fare.

Are there multiple airports in Santo Domingo and Guayaquil?

If your departure or arrival city has more than one airport, it's worth comparing all of them for timing and pricing.

• Airports in Santo Domingo: La Isabela is an alternative to Santo Domingo - Las Américas.
• Airports in Guayaquil: Guayaquil is the only airport currently running.

If you're traveling with a group or bulky luggage, look into parking or transport options. Alternative airports may offer faster transfers or better rates.

Explore flights from Santo Domingo to Guayaquil your way

On Jetcost, you can filter by round-trip or one-way, time of day, airline, number of stops, and even by specific travel agency.

Other popular destinations

Also interested in Ecuador? Check out: Cuenca, Galapagos Islands, Guayaquil, Manta (Eloy Alfaro), Quito.

If you’re flexible with dates, try checking the days before and after to see if prices vary. Some routes are offered by multiple agencies — comparing fares can really pay off.