How much is a flight from Panama City to Santo Domingo La Isabela?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Panama City and Santo Domingo.

Pick a travel date to see today’s available fares.

Fares change often — checking several times throughout the week can make a big difference. Booking in advance often means access to lower prices for the Panama City - Santo Domingo La Isabela route.

Best airport options between Panama City and Santo Domingo

If you're open to flying into or out of more than one airport, you’ll have more routes to compare.

• Airports in Panama City: Panama City is served by 2 airports - Pacífico International Airport, Paitilla.
• Airports in Santo Domingo: Santo Domingo - La Isabela is the sole airport currently available.

Some airports offer extras like lounges, fast track, or self check-in — good to keep in mind. Comparing airports by services offered helps you balance cost and comfort.

Adjust your flight filters for Panama City – Santo Domingo La Isabela

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Other popular destinations

Planning a trip to Dominican Republic? These cities are popular too: La Romana, Puerto Plata, Punta Cana, Santiago, Santo Domingo.

Sorting options let you see the most affordable flights first. Some results may include extra fees shown only at checkout — always read carefully to see what’s included.