What’s the cost of a flight from Panama City to Santiago de Cuba?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Panama City and Santiago de Cuba.

Choose a date to explore the best fares now.

If possible, avoid holiday periods: ticket prices tend to rise quickly and availability drops, especially on busy routes. Morning and evening flights are often in high demand too — book early to get a good fare.

Are there alternative airports near Panama City and Santiago de Cuba?

The two cities are about 1269 km apart. Looking beyond the main airport might reveal better options.

• Airports in Panama City: There are 2 airports in Panama City - Pacífico International Airport, Paitilla.
• Airports in Santiago de Cuba: Only Santiago de Cuba is active at the moment.

Many smaller airports are connected by direct buses or shuttles, often at low cost. If Santiago de Cuba has more than one airport, you can pick the most convenient for your destination.

Customize your flight from Panama City to Santiago de Cuba

Jetcost allows you to filter by travel dates, duration, layovers, carriers, and booking providers. You’ll find direct and connecting flights, one-way or round-trip, from the best airlines and travel agencies.

Other popular destinations

Thinking about Cuba? You might also consider: Havana, Holguin, Santa Clara, Santiago de Cuba, Varadero.

You can sort results by price, duration, or departure time to find the best option for you. When available, results always include both low-cost and traditional airlines.